منابع مشابه
Breast cancer chemoprevention--an update.
This article reviews the recent findings of the IBIS-1 and ATAC trials regarding the role of tamoxifen and anastrozole in the chemoprevention of breast cancer. It also emphasises the need to individualise chemoprevention strategies, and to identify high-risk women who are most likely to develop oestrogen receptor (ER)-positive breast cancer. The prevention of ER-negative disease requires furthe...
متن کاملProgress in breast cancer chemoprevention.
Over the past years there have been significant advances in breast cancer treatment and early detection. For the first time, a decrease in cancer mortality has been observed. Recently, much progress has been made in the understanding of carcinogenesis partly due to available new technologies to detect early molecular changes in the tissue. The knowledge of breast cancer carcinogenesis has provi...
متن کاملSelection criteria for breast cancer chemoprevention subjects.
Early phase chemoprevention trials differ from standard therapeutic clinical trials because asymptomatic, healthy people are treated with a potentially toxic intervention for a prolonged period of time. Current subject selection protocols have relied upon epidemiological methods to identify high-risk individuals. Most available data provide risk estimates for various individual risk factors, bu...
متن کاملWomen's interest in chemoprevention for breast cancer.
BACKGROUND Chemoprevention is the use of pharmacologic or natural agents to inhibit the development of cancer. Tamoxifen citrate is the only approved chemopreventive agent for breast cancer. We sought to determine whether women are interested in taking a drug to prevent breast cancer and to assess the relationship between objective and subjective breast cancer risk and interest in chemopreventi...
متن کاملChemoprevention of breast cancer: recommendations and rationale.
• The U.S. Preventive Services Task Force (USPSTF) recommends against the routine use of tamoxifen or raloxifene for the primary prevention of breast cancer in women at low or average risk for breast cancer. (See “Clinical Considerations” for a discussion of risk.) D recommendation The USPSTF found fair evidence that tamoxifen and raloxifene may prevent some breast cancers in women at low or av...
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ژورنال
عنوان ژورنال: Nature Reviews Clinical Oncology
سال: 2011
ISSN: 1759-4774,1759-4782
DOI: 10.1038/nrclinonc.2011.102